Grem2 mediates podocyte apoptosis in high glucose milieu
نویسندگان
چکیده
منابع مشابه
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Podocyte apoptosis contributes to the pathogenesis of diabetic nephropathy (DN). However, the mechanisms that mediate high glucose (HG)-induced podocyte apoptosis remain poorly understood. Conditionally immortalized mouse podocytes were cultured in HG medium. A chemical inhibitor or a specific short-hairpin RNA (shRNA) vector was used to inhibit the activation of the Notch pathway and the PI3K/...
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ژورنال
عنوان ژورنال: Biochimie
سال: 2019
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2019.02.015